Abstract
BackgroundIn order to attain the objectives set out in the global technical strategy against malaria 2016–2030, it is important to have accurate epidemiological data on malaria in all age categories, including those which are often neglected because of an apparent low burden of disease. The current systematic review with meta-analysis synthesizes the epidemiology of clinical congenital and neonatal malaria in endemic areas.MethodsPubMed, EMBASE, Global Index Medicus, and Web of Science were searched up to 30th October 2019, to identify observational studies reporting on congenital (0–7 days) and neonatal (0–28 days) malaria. No restriction related to language was applied. Study selection, data extraction, and methodological quality assessment were performed independently by two investigators. A random-effects meta-analysis was used to pool prevalence data. Prevalence were adjusted taking into account the variance due to diagnostic method and regional distribution. Subgroup analyses were performed to identify sources of heterogeneity in case of substantial heterogeneity. This review was registered in PROSPERO with number CRD42020150124.ResultsThe bibliographical search identified 1,961 studies, of which 22 were finally retained with a total population of 28,083 neonates. The overall crude prevalence of clinical congenital malaria was 40.4‰ (95%CI 19.6–67.7; 17 studies). The adjusted prevalence considering the variance due to difference in region/country (hierarchical model) was 33.7‰ (95%CI 6.9–77.2). There was no difference between the prevalence of clinical congenital malaria in Africa 39.5‰ (95%CI 17.2–59.5; 15 studies) and outside Africa 56.3‰ (95%CI 0.0–406.1), p = 0.867. The overall crude prevalence of clinical neonatal malaria was 12.0‰ (95%CI 1.4–30.3; 12 studies), and the adjusted one (considering the variance due to diagnostic method and the region/country) was 12.9‰ (95%CI 0.1–39.7). There was no difference between the prevalence of clinical neonatal malaria in Africa 12.1‰ (95%CI 1.3–31.2; 11 studies) and outside Africa 12.5‰ (95%CI 0.0–52.9), p = 0.802.ConclusionThis study suggests a high prevalence of clinical congenital and neonatal malaria. It calls for an intensification of preventive measures against malaria during pregnancy and in the neonatal period, and to consider neonates as a distinct age category in the elaboration of malaria treatment and prevention guidelines.
Highlights
In order to attain the objectives set out in the global technical strategy against malaria 2016–2030, it is important to have accurate epidemiological data on malaria in all age categories, including those which are often neglected because of an apparent low burden of disease
All countries outside Africa where in the control phase of malaria elimination, while those on the African continent were in endemic areas
The funnel plot (Additional file 1: Fig. S2) for congenital malaria studies suggested asymmetry confirmed by the Egger test (p = 0.001). This was not the case for neonatal malaria where there was some symmetry in the funnel plot (Egger test p = 0.1004) (Additional file 1: Fig. S3). This first systematic review with meta-analysis of 28,083 neonates living in 14 endemic malaria countries points out a high prevalence of clinical congenital and neonatal malaria, with a substantial heterogeneity not explained by the geographical location of the study endemic area and diagnostic method used
Summary
In order to attain the objectives set out in the global technical strategy against malaria 2016–2030, it is important to have accurate epidemiological data on malaria in all age categories, including those which are often neglected because of an apparent low burden of disease. Considerable efforts have been made to reduce the global burden of malaria [1,2,3]. In 2018, 19 sub-Saharan African countries and India bore 85% of the world’s malaria burden, with 94% of malaria-related death occurring in sub-Saharan Africa [1]. These data point out difficulties in achieving the global technical strategy against malaria 2016–2030, which aims to reduce malaria morbidity by at least 40% in 2020 [1] This calls for intensified efforts, in the regions of the world most affected by malaria
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
