EPIDEMIOLOGY OF BENIGN PROSTATIC HYPERPLASIA (BPH)

Abstract

ABSTRACT: Several mechanisms appear to be involved in the pathophysiology of Benign Prostatic Hyperplasia. These represent tissue modifications such as age related to hormonal disorders and metabolic syndrome as well as inflammation (Briganti et al, 2009, Vignozzi et al, 2016, Sebastianelli et al, 2018). The Tsimane are a key case study to understand the etiology of Benign Prostatic Hyperplasia as they have low levels of obesity and metabolic syndrome as well as lower levels of Testosterone compared to men of similar age in the US lacking BPH. In general, these data suggest that BPH may not be an inevitable part of male aging during human evolutionary history (Trumble et al, 2015). Given the high prevalence of BPH both in the world and in Peru, it is necessary to investigate what are its factors associated with therapeutic and preventive purposes. Material and methods This cross-sectional study included 162 patients aged ≥ 60 years of the clinical history of the Sermedial Clinic laboratory with and without BPH. The results of standard biochemical and cardiological tests (Glucose, Triglycerides, HDL - Cholesterol, Uric Acid, Systolic Blood Pressure and Diastolic Blood Pressure) and their body composition (Age, Weight, Size, Waist Circumference, Index of each patient were recorded for each patient). Body Mass and Conicity Index). The SPSS statistical program was used and the data will be expressed as means  DS. Your will apply ANOVA as well as the Scheffe specificity test to determine differences between quantitative variables between locations, chi square between categorical variables; and Pearson's correlation coefficients (r) to describe association between variables. In all tests p <0.05 will be considered significant. The statistical analysis will be executed with Statistica software (version 7.0; StatSoft Inc, Tulsa, USA). To evaluate the relationship or association between biochemical, cardiac and body factors with BPH Results With statistical significance (p <0.05) BPH is associated with abnormal values of glucose, triglycerides, HDL-cholesterol, uric acid Diastolic Blood Pressure, Body Mass Index and Circumference Waist in men with age ranges from 60 to ≥ 90 years. Conclusion The main finding of our work is the independent, statistically significant association (p <0.05) with biochemical, cardiac and body values that could be reversed with diet and exercise