Abstract
Fasciolosis is a zoonotic infection caused by the trematoda Fasciola hepatica and Fasciola gigantica. Human fasciolosis is endemic in some parts of South America, Africa, Eastern Asia and Europe. High prevalence of human fasciolosis does not necessarily occur in areas where fasciolosis is a major veterinary problem. Infection with Fasciola hepatica has not been reported in humans in Serbia and former Yugoslavia, although a large variety of animals, such as sheep and cattle show infection rates that may reach significant proportions in some areas. Humans can become accidental hosts of this parasite by ingesting contaminated drinking water or plants in an endemic area. Infection with Fasciola hepatica has a variable clinical presentation depending on the stage of the disease. Typical symptoms that may be associated with fascioliasis can be divided by the phases of the disease including the acute or liver phase, the chronic or biliary phase, the obstructive phase, and ectopic or pharyngeal fascioliasis. The diagnosis of human fasciolosis may be problematical and delayed, especially in non-endemic areas, because physicians rarely encounter this disease and a long list of other diseases must be included in the differential diagnosis. The diagnosis of fasciolosis is complex and requires the application of direct an indirect methods of diagnostics: clinical diagnosis, haematological and biochemical findings, parasitological diagnosis, immuno-diagnosis, imaging procedures, liver biopsy. At the Clinic for Infectious and Tropical Diseases in 2005, we recorded the first case of human fasciolosis in a woman from Belgrade, a citizen of Serbia, who developed clinical symptoms of acute fasciolosis after several months of living in Bosnia-Herzegovina. This article reviews the epidemiology and diagnostics of human fasciolosis. .
Highlights
Vet. glasnik 64 (1-2) 127 - 136 (2010) Zorica Daki} i sar.: Epidemiologija i dijagnostika fascioloze ljudi predstavlja osvrt na epidemiolo{ki i dijagnosti~ki aspekt fascioloze ljudi
ka slika ove bolesti je raznovrsna i zavisi od stadijuma infekcije
Espinoza JR, Maco V, Marcos L, Saez S, Neyra V, Terashima A et al Evaluation of Fas2ELISA for the srological detection of Fasciola hepatica infection in humans
Summary
Iako je fascioloza doma}ihivotinja, pre svega ovaca i goveda, zna~ajno prisutna u pojedinim krajevima Srbije i biv{e Jugoslavije, nema dokumentacije, odnosno objavljenih slu~ajeva fascioloze ljudi u Srbiji. Dijagnostika fascioloze ljudi moe da bude komplikovana i dugotrajna, naro~ito u krajevima gde se bolest retko javlja i gde se na nju retko pomi{lja, kao i zbog brojnih bolesti sli~ne klini~ke manifestacije, koje treba isklju~iti. Dijagnostika fascioloze ljudi je kompleksna i podrazumeva primenu direktnih i indirektnih dijagnosti~kih procedura. Dijagnoza se zasniva na klini~koj slici, hematolo{kim i biohemijskim nalazima, parazitolo{kom nalazu, imunolo{koj dijagnostici, tehnikama vizuelizacije patolo{kih promena i biopsiji jetre. Godine je dijagnostikovan prvi slu~aj fascioloze ljudi u Srbiji. Kako su nalazi bili negativni, a zbog nemogu}nosti imunodijagnostike u na{im laboratorijama, serum smo poslali u Institut za tropske bolesti u Hamburgu gde je fascioloza dokazana prisustvom specifi~nih antitela imunoenzimskim testom (ELISA) i potvr|ena imunoblot metodom (IB). U radu su navedena nova saznanja o uzro~niku, specifi~nosti doma}ina, epidemiologiji sa posebnim osvrtom na rizike za nastanak infekcije, kao i novine u dijagnostici
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.