Epidemiological survey of hyperuricemia in the Guangxi urban community residents

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Objective To explore the incidence of hyperuricemia (HUA) in the urban community residents and the related risk factors,and to propose some effective prevention measures.Methods Totally 6 273 urban residents,aged 18-75 years,were screened with cross-sectional analysis in Xiangshan district of community Guilin.Fasting venous blood samples and urine were collected to evaluate blood glucose,renal function,urine routine,urinary albumin,etc.And questionnaire and physical examination were performed at the same time.Results The total incidence of HUA was 23.5％ in the urban community residents,and was 28.4％ in males,which was significantly higher than 19.7％ in females(x 2=1 332.576,P＜ 0.01).The serum uric acid levels were positive related to weight (or body mass index),waist circumference and female age when adjusting serum creatinine (r =0.150-0269,all P＜ 0.01).The serum uric acid levels in males received 1 to 5 years education and uneducated females were highest,which were (411.4 ± 91.2) μmol/L and (330.8 ± 78.6) μmol/L,respectively.The incidence of HUA in uneducated group was highest (33.6％),while lowest in 6 to 10 years education group (22.4％,P＜0.01).The serum uric acid levels in males without work and in females engaged in housework were highest,which were (418.9 ± 107.6) μmol/L and(317.2 ± 76.2) μmol/L,respectively.The incidence of HUA in residents without work was highest (41.0％),while lowest in residents engaged in physical work(17.8％,P＜0.01).Alcohol consumption and smoke influenced significantly on uric acid level,and highest uric acid levels were in the residents frequently drunk [(399.0 ± 97.9) μmol/L] and smoked in the past [(408.3±94.6) μmol/L].Patients with chronic kidney disease and hypertension had high incidences of HUA,which were 29.0％ and 32.0％,respectively.The mean serum uric acid levels were (354.7 ± 103.6)μmol/L and (356.1 ± 93.9)μmol/L in these patients.There was no significant difference of the incidences of HUA between patients with and without diabetes (x 2=0.957,P ＞0.05).Conclusion In the urban community residents of Guangxi,the incidence of HUA is high,and changing lifestyle such as losing weight,controlling obesity,avoiding smoke and restricting alcohol will be effective measures. Key words: Hyperuricemia; Community-base screening; Incidence; Risk factors