Epidemiological study of Respiratory syncytial virus infection in adults during the pandemic of COVID-19

Abstract

IntroductionWhile respiratory syncytial virus (RSV) is one of the most common pathogens in adults admitted to the ICU due to respiratory diseases, no reports regarding the occurrence rate of RSV infections in adults in Japan during the COVID-19 pandemic exist. Patients and methodsWe conducted this retrospective study to examine the exact occurrence rate of RSV infections in adults. We reviewed all patients (>18 years) with any respiratory symptoms who received quantitative polymerase chain reaction (PCR) using nasopharyngeal samples for respiratory viruses by GeneLEAD at the Aichi Medical University Hospital between November 2022 and November 2023. ResultsA total of 541 adult patients who underwent PCR test were enrolled in this study. RSV was identified in 18 cases (3.3%); 8 (1.5%) upper and 10 (1.8%) lower respiratory tract infections. Influenza A and SARS-CoV-2 were found in 10 (1.8%) and 61 (11.3%), respectively. Patients with RSV infections and COVID-19 had more comorbidities than those with Influenza virus infections.As for RSV-associated with lower respiratory tract infection cases, 10 developed acute respiratory failure, resulting in 1 fatal case due to pneumonia and 1 died of septic shock due to ileus. The 30-, 90-day mortality rates were 1 (6%) and 2 (11%) respectively. ConclusionAbout 3% of adults had RSV infections during the COVID-19 pandemic. The outcomes of RSV infections in adults were similar to those by COVID-19. Those with comorbidities should have a preventive method against RSV infections, the same as for COVID-19.