Abstract
Background: The Car Seat Law (2008) aims to minimize the impacts of traffic accidents on children under 10 years old, including the Traumatic Brain Injury (TBI). Objectives: To compare the epidemiological profile of TBI in children under 10 years old before and after the implementation of the Child Seat Law in Brazil. Design and setting: Ecological study in Brazil. Methods: Data was collected from the Ministry of Health, through DATASUS. The decade prior (1998- 2007) and subsequent (2009-2018) to the implementation of the Law were analyzed. The data collected included children of 10 years or less, average length of stay, hospitalizations, deaths, and mortality. Results: The average mortality between 1998-2007 was 2.31, while between 2009-2018 was 1.59, reducing 30.8%. There was also a reduction of 11% in the average stay averages, which went from 3.6 to 3.2 days. There was a 30.7% decrease in the lethality rate, from 2.3 to 1.6. The median of hospitalizations before the Law was 14,230, while afterwards it was 12,851. Conclusion: There was a significant decrease in the average mortality rate, lethality rate and average stay averages since the Law. This may suggest the Law’s effectiveness in protecting children under 10 years of age.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones
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