Abstract
BackgroundThere is paucity of data on the prevalence and distribution of multidrug- Resistant-Tuberculosis (MDR-TB) in the Republic of Congo. Among the challenges resides the implementation of a robust TB resistance diagnostic program using molecular tools. In resource limited settings there is a need to gather data to enable prioritization of actions. The objective of this study was is to implement molecular tools as a best of diagnosing MDR and XDR-TB among presumptive tuberculosis patients referred to reference hospital of Makelekele in Brazzaville, Republic of the Congo.MethodsWe have conducted a cross-sectional study, including a total of 92 presumptive pulmonary tuberculosis patients and who had never received treatment recruited at the reference hospital of Makelekele from October 2018 to October 2019. The socio-demographic and clinical data were collected as well as sputum samples. Rifampicin resistance was investigated using Xpert (Cepheid) and second-line TB drugs Susceptibility testing were performed by the Brucker HAIN Line Probe Assay (GenoType MTBDRsl VER 2.0 assay) method.ResultsFrom the 92 recruited patients, 57 (62%) were found positive for the Mycobacterium tuberculosis complex. The prevalence of rifampicin-resistant tuberculosis (RR-TB) was 9.8% (9/92) and importantly 2.2% were pre-XDR/XDR.ConclusionThis study showed a high rate of rifampicin resistance and the presence of extensively drug-resistant tuberculosis in the study area in new patients. This study highlights the need for further studies of TB drug resistance in the country.
Highlights
Tuberculosis (TB) is a major public health problem worldwide
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The present study showed that the prevalence of rifampicin-resistant tuberculosis (RR-TB) among the 92 participants suspected of having tuberculosis and who had never received treatment was 9.8% (9/92) and importantly 2.2% were pre-XDR/XDR
Summary
Tuberculosis (TB) is a major public health problem worldwide. The World Health Organization (WHO) estimated that there were 9,9 million new people of tuberculosis in 2020, of which 784,000 occurred among PLHIVElion Assiana et al Ann Clin Microbiol Antimicrob (2021) 20:84 and 157, 9000 people were found to have rifampicin resistant tuberculosis (RR-TB) [1]For several decades, the emergence of MDR-TB as well as XDR-TB has been an obstacle to the control of the disease [2, 3]. No national survey on MTB drug resistance has been carried out [7] and there is paucity of data on the prevalence and distribution of MDR-TB in the country. Such information is essential to facilitate effective control measures and the results of these tests are essential for clinicians in the design of the treatment regimen in the management of MDR-TB patients [3]. The objective of this study was is to implement molecular tools as a best of diagnosing MDR and XDR-TB among presumptive tuberculosis patients referred to reference hospital of Makelekele in Brazzaville, Republic of the Congo
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