Abstract
Background: Epilepsy is one of the most common neurologic disorders among children, with a higher incidence in the first year of life. An accurate epilepsy diagnosis is essential for a proper treatment. Objectives: To assess the rates of childhood deaths from epilepsy in Brazil. DESIGN AND SETTING: Descriptive documentary study based on data from 2010 to 2019 in Brazil. Methods: Evaluating data provided by DATASUS, the information department of Brazil’s publicly funded health care system (SUS). Results: 238 infant deaths due to epilepsy were documented in Brazil during the studied period. The Southeast region had the highest rates, representing 31.51% of the total deaths, followed by the Northeast region, 29.83%, the South region, 18.91%, and the North region, 11.34%. Considering the population in each region, the North had the highest relative rates, followed by the Midwest, Northeast, South and Southeast regions. In the years 2017, 2018 and 2019 the highest death rates were documented, a total of 93 (39.08%). Regarding gender, boys had more deaths, 142 (59.66%) and girls 96 (40.34%). The most affected color / race was white, 133 deaths (55.88%), followed by brown, 79 (33.19%). Blacks and Indians registered the lowest rates, 2.52% each. Conclusion: A predominance of infant deaths due to epilepsy is noticed in the North, which points to the need for greater investment in health in this region, since there was a progressive increase in mortality. It was also found that the male gender and white color are risk factors for complications of the disease.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones
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