Abstract
Background: Brazil is the second country in dementia cases prevalence. The populational aging worsens this situation and overloads the healthcare system. Objectives: To analyze the epidemiological data of dementia in the period from 2010 to 2020 in Brazil. Design and setting: Descriptive cross-sectional epidemiological study with patients with Dementia in Brazil between 2010 and 2019. Methods: Study realized using the SUS Hospital Information Systems (SIH/ SUS), with the information provided by the SUS Informatics Department. Results: From 2010 to 2020, Brazil had 170 million dementia cases notifications and 31 thousand hospitalizations. The southeast region had the highest case prevalence (88%), and the North region the lowest (0.36%). The hospitalized patients number per 100.000 inhabitants was highest in the South region (25.11) and lowest in the North region (4.55). The Center-west region had the highest mortality rate (16.43) and the North the lowest (1). 53% of the reported cases were males, being 51% of the hospitalization rate. The mortality rate was higher in female patients (8.58) and 7.18 for male patients. Patients over 70 years accounted for 75% of the deaths. The patients between 30 and 39 years presented the longest average hospital stay (140,6 days). Southeast and South had the longest (122.2) and shortest (15.1) hospital stay in days, respectively. Conclusion: The data showed the disparity among the regions, from hospitalizations to mortality rates. Hence, politics that can embrace the totality of the territory, improving patient comfort, and disease prognostic are needed.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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