Abstract
The objective of the paper was to evaluate the epidemiological characteristics of laryngeal cancer in the Nisava District in the last 10 years. Published data from the Population Cancer Registry (Serbia) for the period 1999 to 2008 was used. Age-standardized incidence and mortality rates were calculated, according to the standard world population. The rates were calculated per 100.000 inhabitants. Population data were obtained from the National Census 2002. Linear trend was calculated, too. During the period 1999-2008, a total number of 440 cases of laringeal cancer was registered – there were 401 (91.1%) males and 39 (8.2%) females. The average age of patients was similar (male: 61.7±10.97 vs female: 61.8±12.3). In the observed period, the average annual standardized incidence rate was 75.39 (145.77 in males and 11.16 in females). Value of linear incidence trend in males was Y=0.5565x+9.422, R2=0.4554 compared tothe linear incidence trend of laringeal cancer in females Y=0.1426x+0.3807, R2=0.3347. During the entire observation period, a total number of 189 deaths of laringeal cancer was registered, 176 (93.1%) in males and 13 (6.9%) in females. The average annual-standardized mortality rate was 15.14 (29.67 in males and 0.17 in females). Value of mortality trend in males was Y=0.5238x+1.3333, R2= 0.4394 compared to the value of mortality trend in females Y=0.0143x+0.3663, R2= 0,0558. In 204 (80.3%) patients, the histological type of cancer was squamous cell carcinoma. According to localization, approximately two thirds had a glottic cancer while one-third of the cancers were supraor subglottic cancers. The research period showed that men suffered more and died from laryngeal cancer, i.e. a slight increase in disease incidence and mortality was observed in men, whereas in females only increase in disease incidence was observed. Acta Medica Medianae 2014; 53(4):10-14.
Highlights
Laryngeal cancer is the second most common malignancy of head and neck (1)
Crude incidence and mortality rates were calculated per 100.000 inhabitants
Among 189 patients who died from laryngeal cancer in the period 1999 to 2008, there were 176 (93.1%) males and 13 (6.9%) females
Summary
Laryngeal cancer is the second most common malignancy of head and neck (1). Increasing incidence trends are seen in Central and Eastern Europe and in the most developing countries, while in North America and Western Europe the incidence and mortality have either leveled off or are decreasing (2).Among females, increasing incidence has been reported from Canada, Italy, Denmark, United States and Australia. Laryngeal cancer is the second most common malignancy of head and neck (1). Increasing incidence trends are seen in Central and Eastern Europe and in the most developing countries, while in North America and Western Europe the incidence and mortality have either leveled off or are decreasing (2). Among females, increasing incidence has been reported from Canada, Italy, Denmark, United States and Australia. Mortality rates from this cancer is particularity high among males from Eastern and Southern Europe. South America (Southern Brazil, Uruguay and Argentina) shows the highest mortality rates in males, worldwide (3). Mortality due to this cancer is very rare among females, accounting for only 0.4% of all deaths due to cancer worldwide
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