Abstract
Background: Data for the global burden of laryngeal cancer (LC) are limited. Methods: We reported the incidence of, disability-adjusted life years (DALYs), and deaths due to LC by age, sex and by social-demographic index (SDI) in all countries and territories during 2007 to 2017, based on data from the Global Burden of Disease (GBD) 2017 study. We also assessed the risk factors for LC-associated DALYs and deaths through a comparative risk assessment framework. Results: Globally, from 2007 to 2017, the age-standardized incidence rate increased by 0.95%, the age-standardized DALY rate decreased by 8.75%, and the age-standardized death rate decreased by 7.66%. The age-standardized incidence, DALY, and death rates in 2017 were all the highest in the low SDI quintile. The middle SDI quintile witnessed the highest percentage changes in age-standardized incidence, DALY, and death rates during 2007-2017. At the GBD regional level, the highest age-standardized incidence, DALY, and death rates in 2017 occurred in the Caribbean, followed by South Asia. East Asia showed the largest increases in age-standardized incidence, DALY, and death rates from 2007 to 2017. At the national level, China and Jamaica reported the largest percentage increases in the age-standardized incidence, DALY, and death rates over the study period. Conclusion: The global age-standardized incidence of LC remain stable. However, the age-standardized DALY and death rates decreased significantly over the study period. Impact: Our findings will be beneficial for developing policies to reduce the disease burden of LC in particular regions or countries.
Highlights
Laryngeal cancer (LC) is one of the most common malignant tumors in the head and neck, and its incidence rate has increased significantly in recent years [1]
A global study has investigated the incidence of LC comprehensively, finding that the estimated annual percentage of age-standardized incidence rate decreased by 0.99% from 1990 to 2017 [6]
The improvements in disease managements, earlier diagnosis and better adoption of integrated therapeutic schemes, the popularity of fiber-optic laryngoscope, Computed Tomography (CT), and Magnetic Resonance Imaging(MRI) examinations contributed to the declined percentage decreases in age-standardized disability-adjusted life-years (DALYs) and death rates in our study [7]
Summary
Laryngeal cancer (LC) is one of the most common malignant tumors in the head and neck, and its incidence rate has increased significantly in recent years [1]. About 95,000 deaths were attributable to LC worldwide in 2018, the age-standardized incidence and mortality rates were 2.0 and 1.0 per 100,000, respectively globally [2]. Some reports have described the epidemiology of LC globally [1, 2], no study has investigated the associations between LC burden estimates and development status in different regions. The effects of various modifiable risk factors on the global burden of the LC DALYs and death have not been investigated. We used data from the GBD 2017 to report the disease burden due to LC in all countries and territories from 2007 to 2017, by region, age, sex, and socio-demographic index (SDI) in terms of incidence, disability-adjusted life-years (DALYs), and death. We assessed the risk factors for LC-associated DALYs and deaths through the comparative risk assessment framework
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