Abstract
BackgroundPolycystic ovary syndrome (PCOS) is associated with an increased cardiovascular disease (CVD) risk and early atherosclerosis. Epicardial adipose tissue thickness (EATT) is clinically related to subclinical atherosclerosis. In the present study, considering the major role of neutrophil gelatinase-associated lipocalin (NGAL) which is an acute phase protein rapidly releasing upon inflammation and tissue injury, we aimed to evaluate NGAL levels and EATT in PCOS patients and assess their relationship with cardiometabolic factors.Methods64 patients with PCOS and 50 age- and body mass index-matched healthy controls were included in the study. We evaluated anthropometric, hormonal and metabolic parameters. EATT was measured by echocardiography above the free wall of the right ventricle. Serum NGAL and high-sensitive C- reactive protein (hsCRP) levels were measured by ELISA.ResultsMean EATT was 0,38 +/-0,16 mm in the PCOS group and 0,34 +/-0,36 mm in the control group (p = 0,144). In the obese PCOS group (n = 44) EAT was thicker compared to the obese control group (n = 41) (p = 0.026). Mean NGAL levels of the patients with PCOS were 101,98 +/-21,53 pg/ml, while mean NGAL levels were 107,40 +/-26,44 pg/ml in the control group (p = 0,228). We found a significant positive correlation between EATT and age, BMI, waist circumference, fasting insulin, HOMA-IR, triglyceride and hsCRP levels in PCOS group.ConclusionsThickness of the epicardial adipose tissue can be used to follow the risk of CVD development in obese PCOS cases. However serum NGAL levels do not differ in patients with PCOS and control group.
Highlights
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects about 5-10% of women of reproductive age and characterized by hyperandrogenism, menstrual disturbance, chronic anovulation and infertility [1]
We found a significant correlation between Epicardial adipose tissue thickness (EATT) and age, body mass index (BMI), waist circumference, fasting insulin, HOMA-insulin resistance (IR), triglyceride and high-sensitive C- reactive protein (hsCRP) in the patients with PCOS (Table 2)
When we evaluate the PCOS patients according to the hsCRP values, 16 patients had hsCRP values higher than 0.5 mg/L and EATT was found to be higher in this subgroup (p = 0.007)
Summary
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects about 5-10% of women of reproductive age and characterized by hyperandrogenism, menstrual disturbance, chronic anovulation and infertility [1]. PCOS is frequently associated with multiple risk factors for coronary heart disease (CHD), including insulin resistance (IR), dyslipidemia, visceral obesity and hypertension [2,3]. It is reported to be associated with elevation of various markers of endothelial inflammation and abnormal endothelial function which plays a critical role in Neutrophil gelatinase-associated lipocalin (NGAL), known as lipocalin-2 is an acute phase protein, that is rapidly released from neutrophils upon inflammation and tissue injury [5]. Polycystic ovary syndrome (PCOS) is associated with an increased cardiovascular disease (CVD) risk and early atherosclerosis. In the present study, considering the major role of neutrophil gelatinase-associated lipocalin (NGAL) which is an acute phase protein rapidly releasing upon inflammation and tissue injury, we aimed to evaluate NGAL levels and EATT in PCOS patients and assess their relationship with cardiometabolic factors
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