Abstract
Human imprinting disorders are caused by the disruption of the balanced monoallelic parent-of-origin specific expression of imprinted genes. Cycles of erasing, establishing, and maintaining CpG methylation at critical genomic regions in spermatogenesis and oogenesis and following fertilization are the major mechanisms for these genes to be imprinted and to regulate metabolism, growth, development, and behavior. Due to opposite imprinting defects, Prader-Willi syndrome (PWS) and typical Angelman syndrome (AS) are two related disorders with distinct neurodevelopmental phenotype.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
