Abstract
Platinum-based chemotherapy in combination with immunotherapy is a standard of care in advanced non-small cell lung cancer (NSCLC) patients. However, some of them will not benefit from this combination. A better understanding of cancer mechanisms and drug resistance is highly needed, and 3D culture models might help to understand cell-cell and tumor cell-microenvironment interactions. Our study aimed to develop a model of tridimensional multicellular tumor spheroids (MCTS) including non-squamous NSCLC cells with various baseline PD-L1 expression with or without tumor microenvironment, to analyze the impact of chemotherapy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
