Abstract
In recent years, in vitro studies, including our own, have shown that re-expression of tumour suppressive microRNAs can alter malignant pleural mesothelioma (MPM) cell line growth, and that dysregulation of microRNAs might contribute to the intrinsic resistance towards the standard therapeutic regimen of platinum/pemetrexed. Since our screening for predictive biomarkers has revealed several candidates, we have recently decided to expand our studies from the three previously analysed microRNAs to a systematic evaluation of a larger number of predictive and prognostic biomarker candidates.
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