Abstract
Thoracic radiotherapy is limited by substantial toxicities, including radiation pneumonitis which is potentially fatal. Functional avoidance radiotherapy that preferentially avoids irradiating normal (ventilated or perfused) lung regions has shown potential to reduce pneumonitis. The primary objective of this single-arm prospective pilot clinical trial (NCT02308709) was to assess the safety and feasibility of functional avoidance radiotherapy with 4-dimensional (4D) computed tomography (CT) ventilation imaging, which only requires a standard-of-care 4D CT scan and image processing/analysis.
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