EP03.08: Association between pulsatility index of uterine arteries, placental volume, weight, blood pressure and maternal blood glucose at week 12 and birthweight

Abstract

To evaluate the association between the mean pulsatility index (PI) of uterine arteries, placental volume, maternal weight, blood pressure, maternal blood glucose at week 12 and birth weight. A cohort study including 121 pregnant/fetuses/newborns. The pregnant women were evaluated at the 12th week and in the immediate postpartum period. Ultrasonography was performed at week 12 (Sansung WS80 Elite device), weight and blood pressure were also measured, as well as fasting glucose. An analysis of variance was performed to determine the association between the mean PI of the uterine arteries, placental volume, maternal weight, blood pressure and maternal blood glucose at week 12 and the adequacy of birthweight. Multiple regression analysis was performed too. The significance level of 5% was considered. The project was approved by the Ethics Committee. The mean blood glucose was 68.4 ± 9.3mg% (ranging from 43 to 96) and there was no association with birthweight (p = 0.12). The mean placental volume was 67.0 ± 24.3 (ranging from 18.5 to 203.1) without association with birthweight (p = 0.31). Mean maternal weight was 57.5 ± 10.55 (ranging from 38.3 and 84.4), without association with birthweight (p = 0.15). The median systolic and diastolic blood pressure were 104 ± 10.0 and 66 ± 10.4, and there was no association with birthweight (p = 0.83 and 0.98). The mean PI mean was 2.40 ± 0.78 (0.57 to 5.24) and this was associated with birthweight, p <0.001, with a mean PI of 2.29 ± 0.64 in the newborn with adequate weight and 4.22 in the small for gestational age. After multiple regression analysis, maternal glycemia (positive association) and PI of the uterine arteries (negative association) remained associated with birthweight. Adequate birthweight was influenced by uterine artery IP (higher PI, lower birthweight) and glycemia (higher blood glucose greater birthweight) evaluated at week 12. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.