Abstract
Advancements in DNA nanotechnology and nanobioengineering allowed the use of DNA as a generic material, as well as a genetic material. Among various DNA-based materials, DNA hydrogels achieve a DNA-based network at the bulk scale. Notably, a recently developed enzyme-based fabrication method established a route to synthesize physically crosslinked networks from DNA. This new class of DNA networks paved the way for creating different forms of DNA materials by utilizing the characteristics of a biofunctional polymer. This Focus Review provides a brief overview of the enzyme-based fabrication method of physical DNA hydrogels and discusses the latest developments in technology and their applications. Recent advancements in DNA nanotechnology and nanobioengineering allowed the use of DNA as a generic material. Notably, an enzyme-based fabrication method of physical DNA hydrogels opened up a route to realize a novel class of DNA-based materials. Different forms of DNA materials with new applications were created by utilizing its unique characteristics. This Focus Review provides a brief overview of the enzyme-based fabrication method of physical DNA hydrogels and discusses the latest developments in the field.
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