Abstract
Water-extracted arabinoxylan (WEAX) can form covalent hydrogels and has potential applications in colon-targeted drug delivery. However, it is not clear which structural characteristics of WEAX gels can better facilitate drug release in the colon as a microbial triggered system. In this study, different rheological properties of WEAX gels were prepared through oxidative cross-linking using glucose oxidase (GOX) with varying amounts for oral colon-targeted released Naja atra neurotoxin (NANT). It was found that the WEAX hydrogel with an adequate strong cross-linking degree minimized NANT loss in the gastrointestinal tract and improved its release in the colon in vitro. Moreover, NANT was fixed to the wall of the gel network by noncovalent binding and could maintain its secondary structure in the WEAX–NANT hydrogel. The WEAX–NANT hydrogel had an obvious analgesic effect in the in vivo mice test. The results revealed that the WEAX–NANT hydrogel with a strong cross-linking degree was better at releasing NANT.
Published Version
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