Abstract
The enantioselective synthesis of optically active ( R)-cyanohydrins generated from several aromatic, heteroaromatic and aliphatic aldehydes and methyl ketones was carried out using almond, peach or loquat meal as ( R)-oxynitrilase sources in diisopropyl ether under micro-aqueous conditions. The micro-aqueous reaction system, which is superior to the conventionally used water-organic biphase reaction system, performed well over the temperature range of 4°C to 30°C.
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