Abstract
AbstractIn the presence of Candida antarctica lipase B, the alcoholytic ring opening of 5‐substituted oxazinones proceeds as kinetic resolution (KR) and affords N‐acyl β2‐amino acid esters in up to 96 % ee, the remaining oxazinones were obtained in up to 99 % ee. In the presence of triethylamine as racemization catalyst, the enzyme‐catalyzed alcoholytic oxazinone opening proceeds as dynamic kinetic resolution (DKR), affording quantitative yields of N‐protected β2‐amino acid esters in high enantiomeric purity (up to 96 % ee). N,C‐double deprotection to afford the β2‐amino acid can be effected without loss of enantiopurity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have