Abstract
Chagas disease, a neglected tropical disease that affects millions of people worldwide, is caused by Trypanosoma cruzi. The surface of this flagellated parasite is coated with a dense layer of glycoproteins, which play key roles in host-parasite interactions. Among these proteins, enzymatic complexes have been identified, which are involved in several biological processes such as host cell invasion, immune evasion, and nutrient uptake. In this chapter, we review the current knowledge on the enzymatic complexes present in T. cruzi surface, including their structures, functions, and interactions with host molecules. We also discuss the potential of these complexes as targets for the development of novel therapies against Chagas disease. Overall, this chapter provides a comprehensive overview of the enzymatic complexes in T. cruzi surface, highlighting their importance in the pathogenesis of Chagas disease and their potential as therapeutic targets.
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