Abstract
Several enzymatic alkoxycarbonylation processes are evaluated for the resolution of trans- N-benzyloxycarbonyl-4-(4′-fluorophenyl)-3-hydroxymethylpiperidine, a chiral intermediate in the synthesis of (−)-paroxetine. Candida antarctica lipase B (CAL-B) catalyzes the enzymatic alkoxycarbonylation with diallylcarbonate with high enantioselectivity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
