Abstract
Herein we report the novel use of essentially anhydrous protic ionic liquids (PILs) as reaction media for performing the smooth kinetic resolution of 1-phenylethanol by Candida antarctica lipase B (CaLB) catalysed acylation with vinyl acetate at 40 °C. Good rates and high enantioselectivities (92–>99%) were observed with suspensions of both the free enzyme and cross-linked enzyme aggregates (CLEAs) of CaLB.
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