Abstract
BackgroundEnuresis Nocturna (EN) is a common disorders in childhood. Although many different underlying pathophysiological mechanisms have been proposed to explain EN, its etiology is multifactorial. Some reports demonstrate that there is an association between EN and allergic diseases.To study (1) the prevalence of EN in children with asthma, (2) to determine the possible risk factors for EN in asthmatic children.MethodsFive hundreds and six children aged 6–14 years-old diagnosed with asthma and 380 age-matched non-asthmatic controls were enrolled into this cross-sectional case–control study. We studied an allergy panel that included skin prick tests with (8 inhalant allergens), total IgE, and blood eosinophil count for both groups. Semi-structured interviews were conducted with the parents of children presenting EN. Factors associated with EN in children with asthma were analyzed using a logistic regression model.ResultsThe prevalence of EN was significantly higher in children with asthma as compared to the controls: 132 (26 %), 43 (11.5 %) respectively (p = 0.001). Emergency visits frequency, and family history of enuresis were higher in the asthmatic children with EN than in asthmatic children without EN. According to the logistic regression analysis, positive pollen sensitization (p = 0.027, OR = 1.94), allergic rhinitis (p = 0.032, OR = 2.36), and high eosinophil count (p = 0.004, OR = 1.40) were independent risk factors for EN in children with asthma.ConclusionThis study showed that the prevalence of EN in children with asthma was higher than in same age controls. Sensitization to pollens, allergic rhinitis and high blood eosinophil count associate to the EN in children with asthma.
Highlights
Enuresis Nocturna (EN) is a common disorders in childhood
We only focused in this study prevalence of primary monosymptomatic EN in children with asthma rather than nonmonosymptomatic EN or secondary EN
A family history of enuresis was more prevalant in children with asthma plus EN than in those presenting isolated asthma (p = 0.034, Table 2)
Summary
Enuresis Nocturna (EN) is a common disorders in childhood. Many different underlying pathophysiological mechanisms have been proposed to explain EN, its etiology is multifactorial. To study (1) the prevalence of EN in children with asthma, (2) to determine the possible risk factors for EN in asthmatic children. Asthma is the most common chronic childhood disease [1]. Various factors have been implicated in the pathogenesis of childhood asthma [2], such as combined contribution of genetic predisposition environmental insults. A great deal of interest has recently been raised concerning the relationship between psychosocial factors and asthma morbidity [3,4,5]. Several theories have been proposed to explain the ıts pathogenesis, such as developmental delay, increased
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