Abstract
Studies on the accumulation of amino acids in the intact, perfused rabbit cornea and on their transfer across the endothelium of de-epithelialized corneas have been made to determine the mode of access of such substrates from their source, the aqueous humor, to their chief site of utilization, the epithelium. The results indicate that arginine enters and is distributed almost exclusively by diffusion whereas glycine, aspartate and a-amino isobutyric acid are concentrated within the cells of the cornea and cross the endothelium by, in addition to diffusion, a process that is saturable and inhibited by ouabain. However, this process does not appear to be a specifically oriented pump driving these amino acids into the stroma, but rather a cellular accumulation that results in enhanced diffusion out of the cell due to the increased concentration gradient.
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