Abstract
Biomolecular machines execute the majority of essential biological processes in cells. Central to the function of these machines are thermally activated, spontaneous structural rearrangements that are governed by the corresponding conformational free-energy landscape. Because of their principal importance, fully characterizing the free-energy landscapes of biomolecular machines and determining how ligands modulate these landscapes in order to drive and regulate the functions of these machines remains a grand challenge in biology.
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