Abstract
Magnetic nanoparticles can be used to load bio–molecules for various biophysical applications. The direct attachment of bio–molecules such as protein and DNA to magnetic nanoparticles may lead to alter their structure. A method to immobilize and store biomolecules for example DNA on to a magnetic nanoparticles surface without much structural alteration is carried out in the present work. DNA is a target for many therapeutic small molecules as therapeutic drugs bind to DNA – interfering with protein factors involved in DNA mechanism, or cleave DNA cross-link – interfering with the cell division. This may find applications in drug interactions study with the stored DNA without much alteration in their structure.
Highlights
Nanomaterials represent a bridge between bulk materials and molecules
The sample purity of ctDNA was determined from the ratio of A /A . 260 280 Glycol chitosan, GC of 1 mg/mL is prepared and refrigerated
The purity of ctDNA sample used for electrostatic entrapment on magnetic nanoparticles was confirmed with the yield of A /A 260 280 of approximately in the range of 1.8 – 1.9
Summary
Nanomaterials represent a bridge between bulk materials and molecules. Various methods of synthesis of nanomaterials for various bio-physical applications were adopted in the reports. An important feature of the nanomaterials synthesis deals with the specified size and shape, since the physico-chemical characteristics especially magnetism depends on the particle size [1]. Pure iron as nanoparticles can be obtained by evaporation of the metal in Argon atmosphere followed by deposition on a substrate. They are not air stable, and are oxidized, resulting in the change or loss of their magnetization [2].Various studies reported for the possibility of metal oxide nanoparticles as ferromagnetic fluids and as nanoparticles covered by ligands or as particles included into rigid matrices like polymers, zeolites etc.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
