Abstract
Summary We have found two kinds of compounds produced by enteric flora which exert influence on hormonal induction of several liver enzymes of host animals. These compounds were separated on Dowex-50W column chromatography into two fractions; absorbed fraction (Fa) and non-absorbed (Fn). Their modes of action on tyrosine transaminase induction are partially different. Fa plays two different roles: (1) amplifying action for tyrosine transaminase induction by cortisone in liver, and (2) stimulation of cortisone secretion from adrenal gland. Fn acts only for induction by cortisone itself in liver. The attacking points of Fa and Fn for the induction by cortisone in liver may be the same. Otherwise, these compounds had the same kind of influence on leucine specific transaminase induction. In the case of serine dehydratase, the compounds appear to act in a different way from tyrosine transaminase type enzyme. It is speculated that Fn interferes directly with the glucagon induction, and that Fa permits the insulin action in much the same way as do some hormones of the pituitary gland. On the other hand, different responsiveness for induction of these enzymes in germ free and conventional animals was recognized. These observations could be explained from the actions of the bacterial compounds described above.
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