Abstract

Perivascular spaces (PVS) are an important part of the glymphatic system of the brain. Enlarged PVS (EPVS) may be an early manifestation of brain microvascular diseases and brain clearance mechanism disorders. There is growing evidence that EPVS plays an important role in the development and progression of cognitive impairment and may be its early warning sign. This article reviews the relationship between EPVS and cognitive impairment. Key words: Cerebral small vessel diseases; Cerebrovascular disorders; Neuroimaging; Cognition disorders; Alzheimer disease

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