Abstract
TEMPO-oxidized cellulose nanofiber (TOCN) particles in powder form are promising for diverse applications due to their biodegradability, easy handling for storage and transport, and other distinctive characteristics. However, TOCN particles disintegrate in aqueous solutions due to their hydrophilic characteristics, limiting their practical application. To improve the water stability of TOCN particles, the addition of cross-linkers is regarded as a highly effective approach. The present study explores the utilization of oxazoline-containing polymers as cross-linking agents to improve the water stability of TOCN particles while preserving the particle shape.The formation of a stable amide ester provides stability in aqueous media and resistance to amine bond cleavage induced by proteins. The oxazoline-cross-linked TOCN particles retain their particle morphology in water for 24 h even in the presence of glycine. The results herein presented demonstrate the feasibility of using oxazoline-containing polymers as cross-linkers of TOCN particles and the potential use of the modified TOCN in practical applications such as antibody-antigen binding.
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