Abstract
Pharmacokinetics employs complex mathematics to study, model, and predict how drugs are absorbed, distributed, metabolized, and excreted by the body. Amikacin, as a model drug with a narrow therapeutic window, requires Therapeutic Drug Monitoring (TDM) to ensure safety. This study developed an Android-based pharmacokinetic calculator, the "Indonesia Pharmacokinetic Calculator" (KFI), to assist clinical practitioners in quickly and accurately calculating pharmacokinetic parameters using patient weight and Amikacin doses as inputs. The application is designed to provide calculations of pharmacokinetic parameters, a pharmacokinetic simulation graph (plasma concentration-time curve), and predictions of individual patient amikacin plasma concentrations to assess therapeutic effectiveness and minimize toxicity risks. The rigorous testing process has demonstrated that KFI reliably produces expected output data, enhancing clinical pharmacy services in Indonesia through the integration of cutting-edge technology. This tool is expected to improve therapeutic outcomes, particularly for sepsis patients, by facilitating accurate and efficient pharmacokinetic calculations.
Published Version
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