Abstract
In recent years, DNA nanotechnology has matured to enable robust production of complex nanostructures and hybrid materials. We have combined DNA nanotechnology with sensitive optical detection to create functional single-molecule devices that enable new applications in single-molecule biophysics, biosensing and superresolution. To improve the sensitivity of DNA detection assays, we created DNA origami optical antennas for metal enhanced fluorescence. Two gold nanoparticles or nanorods enhance the light-matter interactions of dyes and biomolecular assays placed between them. We first discuss the influence of the metal nanostructure on the photophysical properties of dyes. We then show how single molecules can even be detected on a battery-driven portable smartphone microscope using DNA origami nanoantennas [1]. We further present our work on other biosensing applications of DNA origami as well as the possibility of isotropic nanometric superresolution by combining graphene energy transfer with pMINFLUX and DNA PAINT [2].
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
