Abstract
SEVERAL authors have suggested that insulin is involved in inflammatory and hypersensitivity reactions1,2. It is known2,3 that tuberculin-type skin sensitivity reactions to purified protein derivative (PPD) in the guinea-pig can be depressed by alloxan, and this depression can be partially reversed by the administration of insulin2. In the rat1 insulin intensifies inflammatory and immunological reactivity. It was thus of interest to determine whether tuberculin reactions in the rat (a relatively poor reactor to delayed-type hypersensitivity) could be intensified when insulin was given at the same time.
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