Abstract
The in-vitro release characteristics of prednisolone, a very slightly water soluble glucocorticoid, formulated in directly compressed tablets and liquisolid compacts, were studied at different dissolution conditions. According to the new formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile liquid vehicles, can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. It has been speculated that such systems exhibit enhanced release profiles due to the increased wetting properties and surface of drug available for dissolution. In the present study, the potential of liquisolid systems to improve the dissolution properties of water-insoluble agents was investigated using prednisolone as the model drug. Several liquisolid tablet formulations were prepared using a new mathematical model to calculate the appropriate quantities of powder and liquid ingredients required to produce acceptably flowing and compressible admixtures. Liquisolid compacts demonstrated significantly higher drug release rates, in different dissolution media and volumes, compared to tablets prepared by the direct compression method. It was also observed that the drug dissolution rate from liquisolid tablets was independent of the volume of dissolution medium, in contrast to the plain tablets which exhibited declining drug release patterns with decreasing dissolution volumes.
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