FORMULATION AND EVALUATION OF SUSTAINED RELEASE LIQUISOLID TABLETS OF METOPROLOL SUCCINATE

Abstract

L iquisolid technique is the novel concept of drug delivery via the oral route . This technique is applied to poorly water soluble, water insoluble or liphophilic drugs. According to the new formulation method of liquisolid compacts, liquid medi cations such as solutions or suspensions of water insoluble drugs in suitable non - volatile vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. The present research endeavor is directed t owards the development of liquisolid compact for the production of sustained release tablet of water - soluble Metoprolol succinate . Liquisolid compacts were prepared by using Tween 80 as the liquid vehicle or non - volatile solvent , Avicel PH 102 as absorbing carrier and Aerosil 200 as adsorbing coating material. The prepare d liquisolid systems were evaluated for their micromeretic properties and possible drug excipients interactions. P - XRD analysis confi rmed that no change in crystallinity of Metoprolol succi nate Liquisolid compacts . The DSC and IR spectra analysis study ruled out no any significant interaction between the drug and excipients used in preparation of Metoprolol succinate Liquisolid compacts. The tableting properties were falling within acceptabl e limits. The in vitro dissolution study confirmed reduction in d rug release from Liquisolid compacts compared to conventional matrix tablet , in - vivo study was carried out to check the plasma drug concentration . Tween 80 has plasticizer effect by which it can reduce the glass transition temperature of polymer and impart flexibility in sustaining the release of drug from liquisolid matrices. The results showed that wet granulation had a remarkable impact on the release rate of Metoprolol succinate from liqui solid compacts, reducing the release rate o f drug from liquisolid compacts. Key wo rds : Metoprolol succinate, Liquisolid Tablets , Sustained Release, Avicel.