Abstract
We studied the actions of glycyrrhizin on nitric oxide production from macrophages and a macrophage cell line RAW264-7. Although glycyrrhizin did not induce nitric oxide from resting macrophages, it enhanced the production of nitric oxide from IFN-gamma activated-macrophages or RAW cells. Glycyrrhizin also enhanced the production of nitric oxide from macrophages stimulated with the supernatant of con A-activated spleen cells. Further, glycyrrhizin enhanced tumor cell killing by macrophages activated with IFN-gamma. This tumor cell killing was mainly by nitric oxide.
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