Abstract
WE have reported1 an increased response to interferon induction in mice fed a diet containing vitamin C, and have now found a similar phenomenon in vitro. Addition of L-ascorbate to cultures of mouse cells (transformed L cells and normal embryonic fibroblasts) stimulated with polyinosinic acid · polycytidylic acid (poly(rI)·poly(rC)) resulted in increased synthesis of interferon.
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