Abstract
We investigated suppression of food intake by intraperitoneal (IP) injections of peptide YY 3-36 (PYY 3-36) (24, 60, or 150 μg/kg) in rats with ablations of the area postrema (APX) and in controls with sham ablations. In controls, PYY 3-36-induced suppression was modest and short-lived, averaging 20% at most and persisting less than 6 h. The highest dose tested (150 μg/kg) was even less effective than were the two lesser doses after 3 h. APX did not diminish the potency of these effects of PYY 3-36. In fact, the magnitude of suppression produced by the greatest dose of PYY 3-36 in APX rats was significantly greater than in controls and PYY 3-36-induced suppression was still present at 24 h.
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