Abstract
Cyclic 3′,5′-adenosine monophosphate, 5′-adenosine monophosphate, or 2′-adenosine monophosphate markedly enhanced the rate of oxidation of medium-chain fatty acids by rat heart homogenates, as measured by oxygen utilization and carbon dioxide formation from 14C-labeled substrate. These nucleotides did not alter the rate of oxidation of medium-chain acylcoenzyme A derivatives. The activity of a medium-chain fatty acyl coenzyme A synthetase from rat heart homogenates was increased by these nucleotides, and it was suggested that the ability of the nucleotides to enhance fatty acid oxidation by heart homogenates was due to activation of acyl coenzyme A synthetase.
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