Abstract
Previously, we have showed that the cholecystokinin (CCK)-A receptor expression in hypothalamus is closely related with the responsiveness of electroacupuncture (EA)-mediated analgesic effects in rats. In order to confirm this observation more directly in vivo, the EA-mediated analgesic effects are compared between Otsuka Long–Evans Tokushima Fatty (OLETF) rats, the natural knockout rats with the homozygously disrupted CCK-A receptor gene, with Long–Evans Tokushima Otsuka (LETO) rats. They were stimulated at the zusanli (ST36) acupoint without using anesthetics or holders. The tail flick latency (TFL) test was performed to quantify analgesic effects and then the mean TFL increase ratios were calculated. OLETF rats showed a mean increase of 53% and LETO rats showed a mean increase of 31% of TFL. Our results suggest that the analgesic effect of acupuncture is closely related with the amount of CCK-A receptor expression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
