Abstract
Background: Decrease of muscle strength around knee and ankle are considered to contribute several movement disorders in diabetic patient such as an increased risk of falling, altered gait and balance, and increased body sway. In this study, we examine the effect of exercise training on skeletal muscle of type 2 diabetic models. Methods: Otsuka Long–Evans Tokushima fatty (OLEFT) rats, type 2 diabetic models, were divided into an exercise training group (OLETF-EX, n = 3) and a sedentary group (OLETF-SED, n = 3), while Long– Evans Tokushima Otsuka (LETO) rats were used as a control group (LETO-SED, n = 4). The OLETF-EX rats were trained on a treadmill five times a week for 15 weeks. Data were subjected to two-tailed multiple t-tests with Bonferroni correction following an ANOVA. Results: The muscle force per body weight was significantly lower tension in MG muscle of OLETFSED animals than LETO-SED animals. On the other hand, twitch tensions of OLETF-EX animals were preserved. Conclusion: These data suggest that exercise training prevent decrease of muscle strength in type 2 diabetic model.
Highlights
Experimental DesignReceived: September 13, 2016 Accepted: October 21, 2016 Published: October 24, 2016Keywords: Diabetes; Diabetic neuropathy; Muscle strength; Exercise trainingIt is well known that both type 1 and type 2 diabetic patients shows decrease of muscle strength around knee and ankle [1,2]
We examined the effect of exercise training on medial gastrocnemius (MG) muscle and soleus (SOL) muscle strength in Otuska Long-Evans Tokushima Fatty (OLETF) rats
The Otsuka Long–Evans Tokushima fatty (OLEFT) rats were randomly divided into either an exercise training (OLETF-EX, n = 3) or sedentary group (OLETF-SED, n = 3), while the Long– Evans Tokushima Otsuka (LETO) rats were used as a control group (LETO-SED, n = 4)
Summary
It is well known that both type 1 and type 2 diabetic patients shows decrease of muscle strength around knee and ankle [1,2] These impaired motor functions may contribute to several movement disorders in diabetic patient such as an increased risk of falling, altered gait and balance, and increased body sway [3,4,5]. These disturbances, can be improved by exercise training [6]. In contrast to human, endurance-exercise training does not prevent or increase muscle weakness in type 1 diabetic rats [8]. There is a need to examine alterations of muscle strength and effect of exercise using type 2 diabetic models
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