Abstract
In human washed platelets, collagen-induced phosphoinositide turnover was inhibited by indomethacin, an inhibitor of thromboxane A 2 (TXA 2) formation, particularly at lower doses of collagen. This inhibition was counteracted by the addition of 9,11-epithio-11,12-methano-TXA 2 (STA 2), a stable analogue of TXA 2 as well as by the Ca 2+ ionophore A23187. STA 2 and A23187 did not stimulate phosphoinositide turnover markedly, but significantly increased cytoplasmic free Ca 2+ concentrations. The actions of STA 2 were blocked by 13-azaprostanoic acid, a TXA 2 receptor antagonist. These results suggest that TXA 2 is generated during the action of collagen and increases cytoplasmic free Ca 2+ which then stimulates phosphoinositide turnover in cooperation with collagen.
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