Abstract
In this study some generic commercial products of Atorvastatin tablets were evaluated by dissolution test in acid medium by comparing with that of parent drug Lipitor of Pfizer Company. Some of solubilizing agents were studied in formulation of Atorvastatin tablet including; surface active agent and PEG 6000 .The most effective factor was the use of PEG6000 in formulation of Atorvastatin tablet which improved the dissolution and the results of dissolution profile of formulated tablet in this work was bioequivalent to that of Lipitor .The quantitative analysis of this work was performed by using reversed phase liquid chromatography and a proper mixture of mobile phase which give a retention time for Atorvastatin about 6 minutes .
Highlights
Atorvastatin calcium is a synthetic lipidlowering agent
The low compared to the pure Atorvastatin calcium powder in vitro gastrointestinal medium (6) In systemic availability is attributed to hepatic this present study, Lipitor tablet( 20 mg), the first-pass metabolism or mucosa gastrointestinal presystemic clearance (1)
The patent drug formulation of Atorvastatin Calcium tablet is tested for dissolution in acid plasma concentrations of Atorvastatin and medium and the result was about 92 %
Summary
Atorvastatin calcium is a synthetic lipidlowering agent. It is an inhibitor of 3-hydroxydissolution, but it is rather tedious procedure (5). في هرا انثحث ذى أجساء فحص الاَحلانيح قي انوسط انحايضي عهي حثوب الاذوزفاسراذيٍ انًُرجح يٍ قثم عدج يعايم دوائيح
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