Abstract
Inflammatory responses stimulated by Propionibacterium acnes have been shown to be major etiological factors in the pathogenesis of acne. Scutellaria baicalensis, a popular traditional Chinese medicine, has been widely shown to have anti-inflammatory effects. In this study, primary component analysis and primary effective component analysis were conducted. The results showed that wogonin (1.15mg/g S.baicalensis extract) possessed better anti-acne effects than wogonoside (8.71mg/g S.baicalensis extract) in inhibiting the up-regulation of IL-1β and IL-8 level caused by P.acnes via inactivation of the MAPK and NF-κB signaling pathways. To enhance the anti-acne effects of S.baicalensis extract, an environmentally friendly and healthy plant fermentation strategy was used to efficiently convert glycoside-type constituents into bioactive aglycone. S.baicalensis extract was fermented by symbiotic fungus Penicillium decumbens f3-1 to transform wogonoside into wogonin with a conversion rate of 91.0% after 4 days. Fermented S.baicalensis extract (FSE) showed higher potential anti-acne effects than non-fermented S.baicalensis extract (NSE) by inhibiting the up-regulation of IL-1β and IL-8. Thus, P.decumbens-fermented S.baicalensis Extract may be used for developing new anti-acne cosmetic ingredients.
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