Abstract
Calcium sulfate (CaSO4), as a promising tissue repair material, has been applied widely due to its outstanding bioabsorbability and osteoconduction. However, fast disintegration, insufficient mechanical strength and poor bioactivity have limited its further application. In the study, CaSO4 scaffolds fabricated by using selective laser sintering were improved by adding 45S5 bioglass. The 45S5 bioglass enhanced stability significantly due to the bond effect of glassy phase between the CaSO4 grains. After immersing for four days in simulated body fluid (SBF), the specimens with 45S5 bioglass could still retain its original shape compared as opposed to specimens without 45S5 bioglass who experienced disintegration. Meanwhile, its compressive strength and fracture toughness increased by 80% and 37%, respectively. Furthermore, the apatite layer was formed on the CaSO4 scaffolds with 45S5 bioglass in SBF, indicating good bioactivity of the scaffolds. In addition, the scaffolds showed good ability to support the osteoblast-like cell adhesion and proliferation.
Highlights
The development of suitable bone scaffold for the repair of bone defects is an important challenge in bone tissue engineering [1,2,3,4]
The results showed that only the peak of CaSO4 was detected in all scaffolds, which revealed that the addition of 45S5 bioglass did not alter the phase composition of CaSO4 scaffolds and was consistent with the results of another researcher [23]
Based on the analyses showed that the CaSO4 scaffolds with 45S5 bioglass can induce formation of the bone‐like obviousapatite increased forming ability of apatite, the scaffolds with 45S5 bioglass were expected to form a within four days, indicating that the scaffolds possessed good bioactivity
Summary
The development of suitable bone scaffold for the repair of bone defects is an important challenge in bone tissue engineering [1,2,3,4]. The scaffold should possess proper stability in order to keep the shape in the process of bone repair [8]. Calcium sulfate (CaSO4 ) has been used extensively as bone defects fillers on account of the superb biocompatibility and osteoconductive, which can degrade and be resorbed completely by surrounding bone tissue [9,10,11,12]. CaSO4 fails to provide effective support for the defect site in the process of bone repair, due to its fast disintegration and poor mechanical strength [13]. The adhesion and proliferation of osteoblast‐like cell on the scaffolds were investigated through SEM and fluorescent microscope
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