Abstract
Abstract The inhibitory magnitude of aflatoxins of the B and G series, enzy‐matically bioactivated by rat liver (S9) homogenate, on interferon‐α/β induction by influenza virus in rhesus monkey kidney (LLC‐MK2) cell monolayers was studied. Inhibition of interferon induction followed a structure‐activity series with decreasing potency in the order aflatoxin B1 > G1 > B2 > G2 by both nonactivated and bioactivated aflatoxins. The quantity of bioactivated aflatoxin of all types required to achieve 50% inhibition of interferon induction was fourfold less than that of aflatoxins alone. Dose‐response relationships between aflatoxin quantity and interferon inhibition were evident under all conditions relative to aflatoxin type and bioactivation status. That higher levels of Sendai virus growth were attained in nonactivated and bioactiyated aflatoxins (B1 and G2)‐pretreated cells than in untreated cell monolayers was related to decreased production of interferon by aflatoxins. The ability of interferon to confer ce...
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Schedule a callMore From: Journal of Environmental Science and Health . Part A: Environmental Science and Engineering and Toxicology
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