Abstract
Bioceramics are widely recognized as suitable biomaterials in bone tissue engineering for their osteogenic properties. In this study, 3D printed dicalcium silicate with aluminum ions solid solution (Al–C2S) scaffolds were produced effectively using the compound of preceramic resin, CaCO3, and Al2O3 active powders. The scaffolds exhibited symmetrical and well-proportioned macropores (ca. 400 μm). The proliferation and osteogenic genetic expression levels (osteocalcin, osteopontin, Collagen type I, and Runx2) of rat bone mesenchymal stem cells (rBMSCs) could be enhanced by aluminum ions solid solution in dicalcium silicate scaffolds (C2S), and Al–C2S emerged as a better osteoconductive ability in vivo tests. Therefore, 3D printed Al–C2S scaffold is a promising biomaterial to be applied in bone regeneration.
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