Abstract
DNA-binding transcription factors (TFs) recognize and bind specific DNA sequences found at gene control elements to recruit and regulate the transcription machinery. The TF’s recognition of the target site on an ocean of genomic DNA requires an efficient mechanism for DNA scanning. Traditionally, this problem has been formulated in terms of the facilitated diffusive search for one target site on non-specific DNA. However, our group recently found that the engrailed homeodomain (EnHD) binds promiscuously to any variation of its target site with a ladder of affinities.
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