Abstract
This study aims to characterize chemical groups of metabolites in extracts of Acanthospermum hispidum and Croton zambesicus, and to evaluate their anti-inflammatory activities and their immunomodulatory effect on two pro-inflammatory cytokines (TNFα and IL6). The phytochemical screening was done on the powders of both plants by staining and precipitation reactions. Anti-inflammatory activity was performed in vivo on rat paw edema induced by 2% formalin and immunomodulatory activity was performed in vitro on rat Peripheral Blood Mononuclear Cells (PBMC) stimulated by Lipopolysaccharide (LPS). The leaves of the plants contained important chemical groups such as: cachectic tannins, flavonoids, terpenes, saponosides and quinones. The ethanolic extracts of the two plants studied showed good anti-inflammatory activity by reducing the volume of the rat paw edema induced by 2% formalin and by inhibiting the production of TNFα, IL6 by PBMC of rats stimulated by LPS. Key words: Acanthospermum hispidum, Croton zambesicus, extracts, phytochemical screening, biological activities.
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